Melanotan 2
Melanotan 2 explained
Melanotan 2 (MT-2) is a synthetic cyclic peptide modeled on alpha-MSH, the melanocyte-stimulating hormone that signals melanocytes to produce pigment. It was developed at the University of Arizona in the 1980s and 1990s. MT-2 is shorter than alpha-MSH and is cyclized through a lactam bridge, which makes it more stable and longer-lasting than the native hormone.
Unlike more selective analogs, MT-2 binds several melanocortin receptor subtypes, including MC1R, MC3R and MC4R.
Investigated topics
Because MC1R governs pigment production in skin, MT-2 has been studied in melanocyte cell culture and animal models of melanogenesis. Its activity at central MC3R and MC4R receptors has also made it a research tool for appetite and behavioral signaling in rodents. PT-141 was later derived from MT-2, and the two are frequently compared in receptor research. Investigators have also looked at how MT-2 influences melanocyte response to ultraviolet light in culture, and at its binding affinity relative to the native hormone. Because it activates several receptor subtypes at once, it is often paired with more selective ligands so that each receptor’s contribution can be separated. That broad profile, a drawback for some questions, is exactly what makes it useful for others.
The MT-2 vial
This page lists one Resolve product: the Melanotan 2 vial. It is lyophilized peptide in a sealed vial with the content stated on the label. There are no capsule or liquid-spray versions of MT-2 in the catalog.
- Family: melanocortin receptor agonist
- Structure: cyclic peptide, alpha-MSH analog
- Format: freeze-dried, sealed vial
Check before use
Each MT-2 lot has its own certificate of analysis. Note the lot on your vial, then find that certificate in COA / Lab Reports and confirm the compound name and quantity match the label. We are steadily filling the list in, and our support team can check a lot by email.
For use in laboratory research only.