Peptide Vials
IGF-1 LR3 Vial
IGF-1 LR3 (Long R3 IGF-1) is an 83-amino-acid analog of insulin-like growth factor 1 engineered for reduced binding-protein affinity. Lyophilized vials in 0.1 mg and 1 mg.
Identity & storage
- CAS number
- 946870-92-4
- Molecular weight
- Approximately 9111 g/mol (folded LR3 reference)
- Storage
- Keep the unopened vial sealed and protected from light and moisture. Follow the temperature instructions on the product label. After preparing a solution, follow your laboratory’s validated storage protocol.
Certificate of analysis View available reports and lot details
Product identification & intended use
SKU: RES-9897
For laboratory research use only. Not for human or veterinary use.
Description
IGF-1 LR3 — short for Long Arg3 Insulin-like Growth Factor-1 — is a modified version of human IGF-1 with an arginine substitution and a 13-amino-acid extension. Those changes sharply reduce binding to IGF-binding proteins, so it stays active much longer in cell-culture systems. Resolve BioLabs supplies IGF-1 LR3 in 0.1 mg and 1 mg lyophilized vials.
What is IGF-1 LR3?
Natural IGF-1 is a 70-amino-acid hormone produced mainly in the liver in response to growth hormone. Most circulating IGF-1 is held by binding proteins (IGFBPs), which limits how much is free to act. In IGF-1 LR3, the glutamic acid at position 3 is replaced with arginine (the “R3”) and a 13-residue N-terminal extension is added (the “Long”), giving an 83-amino-acid protein. It was developed largely as a cell-culture growth supplement, where it remains widely used.
IGF-1 LR3 specifications
| Length | 83 amino acids |
|---|---|
| Modifications | Glu3→Arg substitution + 13-residue N-terminal extension |
| Molecular weight | Approximately 9111 g/mol (folded LR3 reference) |
| CAS number | 946870-92-4 |
| Synonyms | Long R3 IGF-1, LR3-IGF-1 |
| Form | Lyophilized powder |
| Strengths | 0.1 mg, 1 mg per vial |
| Catalog reference | RES-9897 |
Research background
IGF-1 LR3 is used in research on IGF-1 receptor signalling (PI3K/Akt and MAPK pathways), muscle-cell (myoblast) proliferation and differentiation, and as a serum-replacement additive in bioprocessing and cell-culture media. Its reduced IGFBP binding makes it a useful tool for separating receptor effects from binding-protein effects.
Format, storage and handling
Keep the unopened vial sealed and protected from light and moisture. Follow the temperature instructions on the product label. After preparing a solution, follow your laboratory’s validated storage protocol.
Testing and documentation
Available reports describe the samples tested. Match the compound, format, strength and lot identifier with your supplied label; a supplier report does not by itself verify current stock. See the report library.
Related research compounds
Also available as IGF-1 LR3 liquid spray (2 mg per 30 mL). Upstream in the growth-hormone axis: sermorelin, CJC-1295 No DAC, ipamorelin. Reconstitute with bacteriostatic water.
IGF-1 LR3 FAQ
What does LR3 mean?
“Long” refers to the 13-amino-acid N-terminal extension, and “R3” to the arginine that replaces glutamic acid at position 3.
How is IGF-1 LR3 different from IGF-1?
It is longer (83 vs 70 amino acids) and binds IGF-binding proteins far less, so it remains active longer in experimental systems.
Why are the vial sizes so small?
IGF-1 LR3 is highly potent in cell and tissue models, so research quantities are measured in fractions of a milligram.
For laboratory research use only. Not for human or veterinary use. Not a drug, food, cosmetic or dietary supplement, and not intended to diagnose, treat, cure or prevent any disease.
